In more mature people, this is essential to grasp as polypharmacy is common and will potentiate the chance of DDIs and ADRs. Consequently, concurrent intake of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and this could increase or minimize efficacy/ADRs of the prescribed tramadol. https://hemalchem.com/product/o-dsmt/