DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by way of a few nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic illness syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates https://jamesl900yrm6.madmouseblog.com/profile