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There's a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors in the dorsal horn to reduce afferent ache transmission and produce analgesia. For that reason, medications like clonidine that focus on alpha-two receptors can influence the transmission of agony. May be provided as monotherapy https://erich801piv0.bimmwiki.com/user

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