You will find a release of norepinephrine within the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors during the dorsal horn to decrease afferent discomfort transmission and produce analgesia. For that reason, medicine like clonidine that goal alpha-two receptors can impact the transmission of pain. Applies to clonidine: oral https://www.proleviate.com/post/the-new-pain-killer-conolidine